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KMID : 0385019960120020203
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Korean Journal of Laboratory Animal Science
1996 Volume.12 No. 2 p.203 ~ p.208
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A Study on the Distribution of NADPH-Diaphorase Positive Neurons in the Cerebral Cortex and Striatum of Apodemus agrarius
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Abstract
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The NADPH-diaphorase histochemical technique provides a simple and robust method to stain select populations of neurons throughout the brain. The NADPH-diaphorase(NADPH-d) positive neurons, uniquely resistant to toxic insults and
neurodegenerative
diseases, have colocalized with neurons in the brain and peripheral tissue containing nitric oxide synthase, which generates nitric oxide, a recently identified neuronal messenger molecule. Nitric oxide acts as a novel neural messenger by
stimulating
soluble guanylyl cyclase thereby increasing the levels of cyclic guanosine 3', 5'-monophosphate in target cells. Thus the NADPH-diaphorase histochemical method allows the direct visualization of the neurons which use this novel signal
transduction
pathway. We now describe the distribution of this enzyme in the Apodemus agrarius brain.
In the cerebral cortex of Apodemus agrarius, NADPH-d positive neurons were observed in all cortical layers, buy they are concentrated into subcortical white matter. In the striatum contained a scattered poplation of medium-sized neurons that were
intensely NADPH-diaphorase positive. These gave rise to a dense fiber network within the striatal neurophil.
Our results suggest a widespread role for the nitric oxide-cyclic guanosine monophosphate system in the nervous system.
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KEYWORD
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